Abstract: Angiopoietin-like 4（ANGPTL4） plays an important role in regulating lipid and glucose metabolism，which depends on the existing knowledge about ANGPTL4. New study has shown a prominent role for ANGPTL4 in tumor angiogenesis， development， metastasis， anoikis resistance and altered redox regulation. In this review, we discuss the regulatory mechanism of ANGPTL4 in tumor and clinical value of it, which can provide more new ideas in the targeted cancer therapy.