Abstract: Objective To explore the expression of the ERRβ in human gastric carcinoma tissues and its clinical significance. Methods The expression of ERRβ in 109 samples of gastric carcinoma and 42 samples of normal gastric tissues were detected by immunohistochemistry. The relationship among ERRβ expression and the clinical data and overall survival（OS）was analyzed. Results The positive ERRβ expression rate of gastric carcinoma was 68.8％， which was significantly higher than that （16.7％） of normal gastric mucosa tissues （P＜0.05）. The expression of ERRβ had correlation with lymph node metastasis， infiltration depth and the differentiation degree in gastric carcinoma （P=0.016， P=0.028， P=0.005）. However， it had no correlation with gender， age and the size of tumor. The median OS of 109 patients was 21.0 months. The median OS of patients with positive ERRβ expression was 11.0 months， which was significantly shorter than 34.0 months of ERRβ negative expression（P＜0.001）. Conclusion The expression levels of ERRβ was increased and correlated with poor prognosis， which may be a powerful molecular marker to predict the progrosis of gastric cancer.