Chinese Clinical Oncology

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Research progress of tumor-infiltrating lymphocytes in triplenegative breast cancer

FANG Hehui, YANG Fang, GUAN Xiaoxiang.   

  1. Department of Medical Oncology, Clinical Medical School of Nanjing University, Nanjing General Hospital of Nanjing Military Command, PLA
  • Received:2016-01-22 Revised:2016-03-29 Online:2016-07-30 Published:2016-07-30
  • Contact: GUAN Xiaoxiang

Abstract: Triplenegative breast cancer(TNBC) is a heterogeneous disease. It is often characterized by the lack of specific therapeutic molecular targets and poor prognosis. There are increasing evidences about the relationship between tumorinfiltrating lymphocytes and the prognosis of TNBC. However, the distinction between different types of T lymphocytes is extremely important, because of their different roles in the tumor microenvironment. Moreover, tumor-associated macrophages have been associated with a relatively poor outcome in TNBC. In this article, we review the role of different lymphocyte infiltration in the clinical outcome of TNBC.

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