Abstract: Objective To investigate the clinicopathological features of uterine adnomatoid tumors in order to improve the diagnostic level of this disease. Methods The clinical and pathological data of 110 adenomatoid tumors of uterus in Changzhou Second People’s Hospital Affiliated to Nanjing Medical University from January 2008 to December 2015 were collected to analyze the clinicopathological characteristics. Results Uterine adnomatoid tumors accounted for 1.55％ in the contemporaneous hysterectomy and uterus-preserving tumor excision specimen. The clinical manifestations were not specific. A total of 109 cases located in the myometrium， one case located in subserous. Microscopically， the tumors were arranged in glandlike， microcystic， trabecular， solid patterns with flat， cuboidal， epithelialoid tumor cells. Immunohistochemical staining showed tumor cells were positive for CK， Vim， HBME-1， D2-40， Calretinin， WT-1， but negative for CD34， EMA. Conclusion Uterine adenomatoid tumor is not rare and easy to be misdiagnosed in clinical and pathological examination. Immunohistochemistry plays an important role in diagnosis
and differential diagnosis of this disease.