Abstract: ObjectiveTo evaluate the value of contrastenhanced ultrasound（CEUS） guided biopsy in hepatic lesions. MethodsA total of 33 patients with 35 lesions underwent contrastenhanced ultrasound guided biopsy from Jan 2016 to Jan 2017 were enrolled in this study. Guided by contrastenhanced ultrasound， the puncture site and needle path were selected and guided realtime biopsy was performed. Puncture successful rate and diagnostic accuracy were calculated. ResultsAll the patients were performed successfully， and each lesion was punctured twice. The puncture successful rate was 1000％. Among 33 patients， 28 cases were diagnosed with malignancies （13 cases of hepatocellular carcinoma， 10 cases of cholangio cellular carcinoma， 3 cases of neuroendocrine carcinoma， 1 case of metastatic urothelial carcinoma and 1 case of metastatic squamous cell carcinoma）， and 5 cases were benign（2 cases of inflammatory lesions， hepatocellular adenoma in 1 case and dysplasia nodules in 2 cases）. The diagnostic accuracy was 1000％. Puncture complication was found in 1 case （small amount of bleeding under hepatic capsule）. ConclusionContrastenhanced ultrasound can clearly display intrahepatic lesions， and realtime biopsy can improve the positive rate of puncture diagnosis.

Key words: Hepatic lesion, Contrastenhanced ultrasound, Puncture, Biopsy