Abstract: Breast cancer is one of the most common malignant tumors in Chinese women. In last decades，the incidence and mortality of breast cancer showed a gradual upward trend. In addition to conventional treatment including early stage resection and radio/chemo-therapy， endocrine therapy and molecular target therapy have been the standard regime for molecular typing breast cancer. However，these malignancies treatment is usually along with recurrence， metastasis，resistance，high toxicity and side effects. Apoptosis blockage is the hallmark of human cancers including breast cancer. Understanding the deregulation mechanisms of apoptosis signal pathway and inducing breast cancer into apoptosis are the most fundamental approach to cure these diseases. This study has summarized the research advances of key apoptotic signal pathways in breast cancer. We hope to explicit the roles of those apoptotic signal pathways and find out the specific molecular target in breast cancer treatment.