Abstract: Objective To investigate the feasibility and dosimetry characteristics of a volumetric arc therapy （VMAT） technique for total body irradiation （TBI）. Methods VMAT technique was performed for fifteen patients receiving TBI therapy as a preconditioning regimen of hemapoietic stem cell transplantation at BenQ Medical Center， between August，2012 and January， 2015. Eclipse 10.0 Treatment Planning system was employed to perform treatment plan. The VMAT plan consisted of three centers： the head and neck， the chest and the pelvis（each with a 360° arcs）. The prescription dose was 12 Gy／6 f. The homogeneity of planning target volume （PTV） and organs at risk （OAR） were measured by dose volume histograms （DVH） curve. Monitor units （MU）， the bean time and total treatment time were prescribed to ensure the efficiency of the VMAT planning. Finally， the 2D ionization chamber array Matrix X was used to verify the VMAT treatment. Results In all patients， there were average MUs of （2308±210.7）MU， and dose rate of 400 cGy／min. The total treatment delivery time was approximately 30 min. Using this technique， the average median dose for PTV was （12.58±0.45）Gy， with a range of（11.27±0.13）Gy to（5.35±0.65）Gy. Simultaneously， a considerable OAR dose reduction of 14.9％～61.9％ was observed by using this planning. Conclusion VMAT technique could obtain dose conformality of PTV， reduce the dose of OAR， and improve the treatment delivery efficiency. And it is expected to facilitate the clinical transition of TBI for the patients with hematologic malignancies.