Abstract: As a new functional imaging technology， contrast-enhanced ultrasound （CEUS） can clearly show the characteristic of blood flow perfusion of the lesions. And we can get the time-intensity curve in the region of interest， which can reflect the level of enhancement varying with time by quantitative analysis software. It can reveal the microvessel density of lesions objectively. Therefore， the quantitative analysis of CEUS can play an important role in the diagnosis of tumor and the evaluation of treatment effect. The paper introduced the mechanism of quantitative analysis of CEUS and its primary parameters， and summarized the role of some parameters in distinguishing benign and malignant liver diseases， assessing the prognosis of hepatocellular carcinoma， as well as evaluating therapeutic effect.