Abstract:  Chemotherapy is an important therapeutic strategy for cancer treatment， however， chemoresistance is a major challenge. Recently， emerging evidences suggest that abnormal changes in the Notch signaling pathway are involved in the development and chemotherapy resistance of human malignancies. Notch signaling pathway is widely expressed in a variety of tumor cells， and it promotes tumor stem cell （CSC） phenotype， epithelial-mesenchymal transition （EMT）， and interaction with other signaling pathways， resulting in tumor resistance to chemotherapeutic drug. Therefore， this article will provide a brief overview of what is currently known about Notch signaling and its related regulatory mechanism. Moreover， down-regulation of Notch pathway could enhance drug sensitivity， which may provide a novel approach for the treatment of cancer.

Key words:  , Cancer">Cancer')">">, Notch signaling pathway, Chemotherapy, Drug-resistance

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