Chinese Clinical Oncology ›› 2018, Vol. 23 ›› Issue (5): 458-462.

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Progression of long chain non coding RNA in the regulation of drug resistance in colorectal cancer

  

  1. Department of Clinical Medicine， the First Clinical Medical College，Nanjing Medical University， Nanjing 210029， China
  • Received:2017-10-07 Revised:2018-01-20 Online:2018-05-31 Published:2018-06-07

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Abstract: Colorectal cancer has the characteristics of high incidence and high mortality. Chemotherapy is one of the conventional treatment methods. The production of tumor resistance is the main reason for the failure of chemotherapy. Long chain non coding RNA （lncRNA） is involved in many physiological and pathological processes， and plays an important role in tumor proliferation， apoptosis， drug resistance and metastasis. Therefore， it is of practical significance to study the role of lncRNA in the drug resistance of colorectal cancer. In this review， we reviewed the progression of lncRNA in drug resistance mechanism of colorectal cancer at home and abroad.

Key words: Colorectal cancer, Long chain non coding RNA（lncRNA）, Chemoresistance

CLC Number: 

  • R735.3
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