Chinese Clinical Oncology ›› 2018, Vol. 23 ›› Issue (5): 467-471.

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The biological effects of neuropilin-1 in the development of gastrointestinal cancers

  

  1. Department of Integrated Chinese and Western Medicine， Medical College of Yangzhou University， Yangzhou 225001， China

  • Received:2018-01-11 Revised:2018-03-21 Online:2018-05-31 Published:2018-06-07

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Abstract: Gastrointestinal cancer is the most common malignant tumor with high morbidity and high mortality. Recently， the role of Neuropilin-1 in the development of digestive tract malignant tumor has become a hot spot. It can regulate the angiogenesis process of malignant tumor， mediate the proliferation and invasion of tumor cells， and thus promote the progression and metastasis of tumor. This article reviews its role in tumor angiogenesis， tumor proliferation and invasion， metastasis and tumor therapeutic targets.

Key words: Neuropilin-1, Gastrointestinal cancers, Biological effects

CLC Number: 

  • R730
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