Abstract: About 10％15％ of breast cancer patients have brain metastases. The incidence of brain metastases will continue to increase with prolonged survival and the control of extracranial metastases. Currently， brain metastases are still important clinical challenges and associated with extremely poor prognosis. The molecular subtypes of breast cancer directly affect the incidence of brain metastases， treatment options and prognosis of patients. The current treatment strategies include local therapy and systemic therapy. This article reviews the relationship between the molecular subtypes of breast cancer and the incidence and molecular mechanism of brain metastases and the treatment methods， aiming to improve the new ideas for the individualized diagnosis and treatment of breast cancer patients with brain metastases and multidisciplinary management.

Key words: Breast cancer, Brain metastasis, Treatment