Abstract: In the progression of breast cancer, brain metastasis will occur in 15% to 30% patients. Due to the prolonged survival of breast cancer patients, the incidence of brain metastasis is gradually increasing. The incidence and characteristics of brain metastasis from breast cancer of different molecular subtypes are different. Current treatment for breast cancer brain metastasis includes local treatment and systemic treatment. In recent years, with the development of comprehensive treatment of breast cancer, the application of chemotherapy, endocrine therapy and molecular targeted therapy in breast cancer brain metastasis has received more and more attention. Many new treatment methods such as conjugated drugs, immunotherapy and other methods have also shown certain effects on breast cancer brain metastasis. This article reviews the clinical characteristics and treatment progress of different molecular subtypes of breast cancer brain metastasis, and aims to provide certain ideas and basis for the clinical diagnosis, treatment and management of breast cancer brain metastasis.

Key words: Breast cancer；Brain metastasis">；Brain metastasis；Molecular subtypes">；Molecular subtypes；Clinical characteristics">；Clinical characteristics；Treatment')">">；Treatment