Chinese Clinical Oncology

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Clinical outcome of intensity-modulated radiotherapy for hypopharyngeal carcinoma and influences on hypopharyngeal function

CHEN Zhenzhang,HUANG Shengfu,ZHU Xiangzhi,JIANG Xuesong,ZHOU Yiqin,LIU Juying,GUO Wenjie,HE Xia,ZHANG Yiqin   

  1. Department of radiotherapy,Jiangsu Tumor Hospital,Nanjing 210009,China
  • Received:1900-01-01 Revised:1900-01-01 Online:2013-11-30 Published:2013-11-30

Abstract: Objective To explore clinical outcomes of intensity-modulated radiotherapy(IMRT)for hypopharyngeal carcinoma without distant metastasis,and the hypopharyngeal function after radiotherapy. Methods Thirty-five cases were retrospectively reviewed from April 2007 to October 2012. All patients received radical IMRT with or without chemotherapy. The prescribed dose for gross tumor volume(GTV)and GTV2 was 66-70Gy. Results All patients were followed up. The median follow-up time was 16 months(range 5-59 months). Locoregional recurrence occurred in 9 cases, and distant metastasis was observed in 3 cases. The rates of 2-year locoregional control,2-year disease free survival and 2-year overall survival were 71.9%,66.1% and 55.6%, respectively. Seven of 13 patients died of locoregional recurrence, 3 of distant metastasis. The 2-year functional laryngeal rate was 91.7%. Conclusion IMRT can improve the locoregional tumor control rate and retain the hypopharyngeal functions for patients with hypopharyngeal carcinoma. However,locoregional recurrence is the main reason for treatment failure.

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