Chinese Clinical Oncology
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CHEN Zhenzhang,HUANG Shengfu,ZHU Xiangzhi,JIANG Xuesong,ZHOU Yiqin,LIU Juying,GUO Wenjie,HE Xia,ZHANG Yiqin
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Abstract: Objective To explore clinical outcomes of intensity-modulated radiotherapy(IMRT)for hypopharyngeal carcinoma without distant metastasis,and the hypopharyngeal function after radiotherapy. Methods Thirty-five cases were retrospectively reviewed from April 2007 to October 2012. All patients received radical IMRT with or without chemotherapy. The prescribed dose for gross tumor volume(GTV)and GTV2 was 66-70Gy. Results All patients were followed up. The median follow-up time was 16 months(range 5-59 months). Locoregional recurrence occurred in 9 cases, and distant metastasis was observed in 3 cases. The rates of 2-year locoregional control,2-year disease free survival and 2-year overall survival were 71.9%,66.1% and 55.6%, respectively. Seven of 13 patients died of locoregional recurrence, 3 of distant metastasis. The 2-year functional laryngeal rate was 91.7%. Conclusion IMRT can improve the locoregional tumor control rate and retain the hypopharyngeal functions for patients with hypopharyngeal carcinoma. However,locoregional recurrence is the main reason for treatment failure.
CHEN Zhenzhang,HUANG Shengfu,ZHU Xiangzhi,JIANG Xuesong,ZHOU Yiqin,LIU Juying,GUO Wenjie,HE Xia,ZHANG Yiqin. Clinical outcome of intensity-modulated radiotherapy for hypopharyngeal carcinoma and influences on hypopharyngeal function[J].Chinese Clinical Oncology, 2013, 18(11): 1009-.
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http://manu65.magtech.com.cn/Jwk3_lczlxzz/EN/Y2013/V18/I11/1009
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