Abstract: Objective To observe the short-term clinical efficacy and toxicity of docetaxel（DOC） and cisplatinum plus 5-fluorouracil（DF） regiman in concurrent chemoradiotherapy for advanced nasopharyngeal carcinoma（NPC）. Methods Sixty-six patients with NPC were divided into DOC group and DF group with 33 patients in each group. Patients in DOC group were given DOC 25mg／m2 iv， once a week for 7 weeks. Thirty-three patients in DF group were given cisplatin（25 mg／m2 iv d1-d3） and 5-fluorouracil（550 mg／m2 civ，d1-d5）. Every 3 weeks was a cycle with a total of 2 cycles. Radiotherapy was given in the two groups. Radiation therapy was applied with 6MV X-ray and 9MeV electronic wire（double neck distinction） from external exposure，and nasopharyngeal target dose was 68-72Gy／6.8-7.2weeks. Results The efficacy could be evaluated in all patients. In DOC group，20 cases were of CR， 10 of PR， 3 of SD， and response rate（RR）was 90.9％； in DF group，21 cases were in CR， 10 i n PR， 2 in SD， and RR was 93.9％. The differences of RR in the two groups had no significance（P＞0.05）. The main toxicities were neutropenia， oral mucositis， dermatitis and digestive reation. The occurrence rates of neutropenia and oral mucositis in DF group were higher than those in DOC group（P＜0.05）. Conclusion DOC in concurrent chemoradiotherapy for advanced NPC was with good efficacy and less toxicities，which can be used as a new option for advanced NPC.