Abstract: Objective To study the association between coagulation function and pathological types and stages in patients with lung cancer.
Methods A total of 76 patients from the Department of Cardiothoracic Surgery of the First Affiliated Hospital of Nanjing Medical University from January 2012 to June 2012 were enrolled in the study. The levels of plasma tissue factor（TF）, Ddimer, plasma fibrinogen（FIB）, fibrinogen degradation product（FDP） and platelet couts were detected and compared in patients of different clinical stages and pathological types.
Results The plasma TF，D-dimer levels were significantly higher in patients with stage Ⅲ，Ⅳ than those in stage Ⅱ （P＜0.05）. The TF, D-dimer levels were higher in adenocarcinoma than those in squamous cell carcinoma（P＜0.05）. Conclusion Patients with lung cancer are in high hypercoagulable state， which are significantly relevant with clinical stages and pathological types of malignant tumors， it may be served as prognostic marker for lung cancer.