Abstract: Tolllike receptors are the specific type Ⅰ transmembrane receptors and pathogen pattern recognition receptors in the innate immune system and play an important role in acute inflammatory response，cellular signal transduction and apoptosis. Recent research indicate that many kinds of tumor cells express several TLRs. Some may be related to immune escape and tumor progression， but others may be involved in the antitumor immune responses. In this review，we summarize the main TLRs known to be expressed by breast cancer cells and their associated signal transduction pathways.