Chinese Clinical Oncology

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Research advance in gamma delta T cells and its antitumor activity

SU Dan,WANG Dongliang,ZHANG Yanqiao   

  1. Department of Gastroenterology,Harbin Medical University Cancer Hospital
  • Received:2013-09-16 Revised:2013-11-21 Online:2014-04-30 Published:2014-04-30
  • Contact: ZHANG Yanqiao

Abstract: Gamma delta(γδ) T cells are minor subset of T lymphocytes(2%-5% of peripheral blood T lymphocytes) that express Vγ9Vδ2 T cell receptors, mainly distributed in the mucosaassociated lymphoid tissue, are nonrestricted cells of major histocompatibility complex(MHC), can kill various tumor cells. Many data demonstrate that γδ T cells are involved in the first line of immune defense system. In the future, adoptive γδ T cellsbased cell immunotherapy will become a new strategy for cancer immunotherapy. In this review, we provide an overview of its antitumor mechanism and clinical application.

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