Abstract: Objective To explore the expressions of nueleophosmin（NPM） and transforming acidic coiled-coil proteins（TACC1） in gastric carcinoma, and analyze their correlation with clinicopathological features and prognosis.
MethodsThe immunohistochemistry was used to detect the expressions of NPM and TACC1 on tissue sections from 130 gastric carcinoma and paired adjacent tissues. Then the relationships between expressions of NPM and TACC1 and clinicopathological variables（age， gender， degree of differentiation， HER-2 status， TNM stage, recurrence and metastasis were analyzed. The overall survival of patients was estimated using the KaplanMeier method. The factors affecting the prognosis of gastric cancer were analyzed by Cox multivariate survival analysis. Results The high-level expression rates of NPM and TACC1 were 65.4％（85／130） and 48.5％（63／130）， higher than 51.5％（67／130） and 32.1％（42／130） of paired adjacent tissues with significant differences（P＜0.05）. The NPM expression was related with degree of differentiation， TNM stage, recurrence and metastasis， and the TACC1 expression was related with TNM stage（P＜005）. Positive correlation was observed between expressions of NPM and TACC1（r=0.220， P＜0.05）. The median overall survival of patients with NPM and TACC1 highlevel expression was 20.0 and 18.0 months, lower than 32.0 and 22.0 months of patients with lowerlevel expression. Multivariate survival analysis showed that NPM and TACC1 expressions may act as independent prognostic factors for gastric cancer（P＜0.05）.
Conclusion Expressions of NPM and TACC1 may be involved in the occurrence and development of gastric carcinoma. They may serve as markers for evaluating the tumor biological behavior and predicting prognosis of gastric cancer patients.