Abstract: Objective To explore the expressions of heat shock protein 70 （HSP70） and p57kip2 and their clinical significance in giant cell tumor of bone （GCT）.
MethodsThe immunohistochemistry was used to analyze the expressions of HSP70 and p57kip2 in tissue sections from 56 GCT tissues. Then， the relationship between their expressions and clinicopathological variables （gender， age， lesion location， histological grading， radiological staging and tumor diameter） or recurrence were analyzed. The Spearman analysis was employed to investigate the correlation between the expressions of HSP70 and p57kip2. Results The positive expression rates of HSP70 and p57kip2 were 51.79％ （29／56） and 21.43％ （12／56）， respectively. The HSP70 expression was related with age， radiological staging， tumor diameter and recurrence（P＜0.05）， and the p57kip2 expression was related with radiological staging and recurrence （P＜0.05）. Negative correlation was observed between expressions of HSP70 and p57kip2 （r=-0.280， P＜0.05）. Conclusion Expressions of HSP70 and p57kip2 may be involved in the occurrence and development of GST. They may serve as markers for evaluating the tumor biological behavior and predicting recurrence of GST patients.