Chinese Clinical Oncology

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Progression on the role of microRNAs in the initiation and progression of triple negative breast cancer

YANG Fang, GUAN Xiaoxiang.   

  1. Department of Oncology,Medical School of Nanjing University, Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002, China
  • Received:2014-02-10 Revised:2014-04-12 Online:2014-10-30 Published:2014-10-30
  • Contact: GUAN Xiaoxiang

Abstract: MicroRNAs (miRNAs) are recently discovered, small singlestrand RNA molecules that can regulate gene expression, and the abnormal expression or mutation in miRNAs are considered to be associated with the initiation and progression of a variety of tumors. It has been identified that miRNAs play a crucial role in triple negative breast cancer, providing a novel possible therapeutic application. In this review, we will provide an overview of the application of miRNAs in triple negative breast cancer.

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