Abstract: With the rapid development of tumor molecular biology， molecular targeted therapy has become the most promising treatment of cancer and the study of molecular targets has been to be a hot topic for a long time. Remarkably， hematopoietic Pbx-interaction protein （HPIP）， a microtubule-binding protein， is a novel scaffolding protein. To date， according to the relevant literature， HPIP is closely associated with tumor growth， proliferation and metastasis. HPIP may be a new target for cancer therapy in the future. We review a representative set of resent studies and summarizes the progress of mechanisms and significance of HPIP in the development of malignant tumors.