Abstract: With the transformation from the traditional biomedical model to bio-psychosocial medical model， psychological problems as malignant tumor etiology have become deeply studied into clinical research. Behavioral medicine research in recent decades indicated that complex psychological factors （such as anxiety， depression， pain， stress） have a certain relationship with the occurrence of some human malignant tumor. The role of psychological factors in treatment of malignant tumor is becoming more and more significant. Negativepsychological mood not only caused adverse effects on neoplastic disease transformation， but also can influence the quality of life of the patients. So in the malignant tumor treatment at the same time we should strengthen thesupport of psychological problems. According to some reports in the literature at home and abroad， this article makes a brief review on the psychological problems of patients with malignant tumor as follows.