Abstract:

Neuroendocrine neoplasm （NEN） is a heterogeneous tumor with variable biological behaviors and clinical pathological characteristics. The prognostic factors include histological grade， tumor size， primary tumor site and metastasis. Compared with other malignancies， neuroendocrine tumors are likely to grow slowly and metastasize early， but bone metastases has relatively good outcome. Both the relatively low incidence and heterogeneity contributed to the paucity of large epidemiological studies. We will review clinical and pathologic features of bone metastasis， imaging traits and therapeutic progress.