Chinese Clinical Oncology
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HOU Lidan, ZHANG Jing, MENG Xiangjun.
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Abstract: Circular RNA (circRNA) as a newly discovered covalently closed circular noncoding RNA, is produced from back splicing and exists in a variety of biological cells, characterized by the stable structure, conserved sequence and some tissuespecificity. Recent studies show that circRNAs function as microRNA sponges to inhibit miRNA activity, involving the regulation of gene transcription and binding with RNAbinding proteins. As the new regulatory molecules, circRNAs play an important role in tumor development and progression, and serve as the novel potential biomarkers,providing new strategies for cancer diagnosis and targeted therapy. Herein, we review the properties, biogenesis, and functions of circRNAs and discuss its role in cancer.
HOU Lidan, ZHANG Jing, MENG Xiangjun. . Research progress of circular RNAs and tumor[J].Chinese Clinical Oncology, 2016, 21(11): 1043-.
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http://manu65.magtech.com.cn/Jwk3_lczlxzz/EN/Y2016/V21/I11/1043
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