Abstract:

Objective To explore the application of methylene blue and carbon nanoparticles suspension injection as lymphatic tracers in laparoscopic radical resection of cervical cancer. Methods Fifty patients diagnosed as cervical cancer from 2015 to 2016 were enrolled in this study， and were randomly divided into methylene blue group and carbon nanoparticles suspension injection group with 25 patients in each group. The detection rate of sentinel lymph nodes （SLN） of the two tracers was compared. Results The detection rate of SLN of methylene blue group and carbon nanoparticles suspension injection group was both 100.0％. In methylene blue group， 22 cases were detected with SLN. There were 48 SLNs in total with an average of 2.2， and the recognition rate was 88.0％. Five patients were found lymph node metastasis. In carbon nanoparticles suspension injection group， 23 cases were detected with SLN. There were 50 SLNs in total with an average of 2.3， and the recognition rate was 92.0％. Four patients were found lymph node metastasis. No obvious side effects were occurred. Conclusion Methylene blue and carbon nanoparticles suspension injection have fairly high recognition rate and detection rate for SLN in laparoscopic radical resection of cervival cancer, and they are safe and worthy of clinical application.