Abstract: ObjectiveTo investigate the expression of long noncoding RNA（lncRNA） CCHE1 （cervical carcinoma highexpressed 1） and its clinical significance in breast cancer tissues. 
MethodsOne hundred and fifteen cases of breast cancer tissues and 78 cases of paired paracancerous tissues were collected in our hospital from January 2011 to December 2012. The expression of CCHE1 was detected in the above tissues by realtime fluorescence quantitative PCR （QPCR）. CCHE1 levels in breast cancer tissues and adjacent tissues were compared. The relationship between the CCHE1 level and the clinicopathological parameters of breast cancer （age， clinical T stage， histological grade， lymph node metastasis， Nottingham prognostic index， Ki67 proliferative index， ER expression， PR expression and HER2 amplification） and recurrence were analyzed. The overall survival （OS） and progressionfree survival （PFS） at different CCHE1 levels were analyzed， and the Cox proportional hazards model was used for multivariate analysis. 
ResultsQPCR detection showed that the level of CCHE1 in 115 cases of breast cancer tissues was 7610±3210， higher than 2142±1753 in 78 cases of adjacent tissues （P＜005）. The level of CCHE1 was significantly related with clinical T staging， lymph node metastasis， Nottingham prognosis index， HER2 amplification and tumor recurrence （P＜005）， but not related to age， histological grade， ER expression， PR expression and Ki67 proliferative index （P＞005）. The median PFS and OS of the CCHE1 lowexpression group were 560 months and 630 months， better than 370 months and 420 months of the CCHE1 highexpression group （P＜005）. The CCHE1 level， clinical T stage， lymph node metastasis， Nottingham prognostic index and HER2 amplification were independent prognostic factors of OS and PFS （P＜005）. 
ConclusionThe increased expression of CCHE1 in breast cancer tissues may play a role in the development of breast cancer， and this lncRNA can be a potential molecular marker for evaluating the prognosis of breast cancer.

Key words: Breast cancer, Long noncoding RNA, Cervical carcinoma highexpressed 1 （CCHE1）, Prognosis