Abstract: ObjectiveTo compare the differences in clinicopathological characteristics and prognosis between gastric cancer with and without neuroendocrine differentiation （NED）. 
MethodsFrom January 2010 to August 2017， 98 gastric cancer with NED and 338 gastric cancer without NED patients with data of clinicopathological characteristics from Nanjing Drum Tower Hospital were collected. The clinicopathological characteristics between the two groups of patients were compared by chisquare test. Survival rate was calculated by KaplanMeier curve， univariate and multivariate prognostic risk factors were analyzed by Logrank test and Cox regression model. 
ResultsThe two groups of gastric cancer patients with and without NED had the following common characteristics： similar onset symptoms， more younger than 65 years old， more bigger than or equal to 4 cm tumor size， high proportion of nerve invasion， and the rates of lymph node and distant metastasis were similar. However， there were some significant diferences in gender， histological types， T stage， tumor TNM stage and vascular invasion between this two groups （P＜005）. The positive expression rates of CgA and Syn were 704％ and 755％， both expression rate was 459％. The 1， 3 and 5 years survival rates in gastric cancer patients with NED were 735％， 462％ and 342％， lower than 889％， 641％ and 537％ in those without NED， and the differences were significant （P＜005）. Univariate analysis showed that age， tumor size， differentiation， TNM stage， vascular and nerve invasion were associated with prognosis of gastric cancer with NED （P＜005）. Multivariate analysis showed that age was an independent factor affecting the prognosis （P＜005）. 
ConclusionImmunohistochemistry is the main method to diagnose gastric cancer with NED. Gastric cancer patients with NED may have poor prognosis.

【Key Words】Gastric cancer；Neuroendocrine differentiation；Prognosis；Chromogranin A；Synaptophysin

Key words: Gastric cancer, Neuroendocrine differentiation, Prognosis, Chromogranin A, Synaptophysin