Abstract: ObjectiveTo investigate the clinical significance of serum albumin （ALB） and prealbumin （PA） in the shortterm efficacy of hodgkins lymphoma （HL）. 
MethodsThe clinical data of 103 patients with HL who were diagnosed as initial diagnosis at 307 Hospital from January 2010 to July 2016 were collected and analyzed retrospectively. Based on the ALB and PA levels before treatment， the shortterm efficacy of HL was analyzed. 
ResultsAmong the 103 patients with HL， complete remission（CR） was achieved in 60 cases（583％）， partial remission（PR） in 37 cases （359％）， and the total effective rate was 942％. Among the patients with ALB＜35 g／L， 7 cases （200％） achieved CR. Among the patients with ALB≥35 g／L， 53 cases （779％） achieved CR. Among the patients with PA＜200 mg／L， 23 cases （383％） achieved CR. Among the patients with PA≥200 mg／L， 37cases （860％） achieved CR. Compared with ALB＜35 g／L group， the patients with ALB＜35 g／L often had B symptoms， advanced stage， extranodal involvement， high IPS score and low CR rate （P＜005）. Compared with PA≥200 mg／L group， the patients with PA＜200 mg／L often accompanied by B symptoms， extranodal involvement， high IPS score， lymph nodal sites≥3 and low CR rate （P＜005）. Multivariate analysis showed that ALB alone was an independent factor for CR in HL. 
ConclusionPretreatment ALB and PA are associated with CR of HL， and have a significant effect on the short term efficacy of HL.

Key words: Hodgkins lymphoma, Efficacy, Serum albumin（ALB）, Serum prealbumin（PA）