Abstract:

Objective To investigate the relationship between preoperative derived neutrophil-to-lymphocyte ratio （dNLR） and clinicopathological characteristics， as well as prognosis of patients with triple negative breast cancer. Methods  The data of 161 patients with triple negative breast cancer receiving operation from 2000 to 2010 were retrospectively reviewed. The optimal cutoff level for the dNLR was calculated with receiver operating characteristics curve （ROC）. The patients were divided into two groups according to the preoperative dNLR： high dNLR and low dNLR. Overall survival （OS） and disease-free survival （DFS） were assessed using the Kaplan-Meier method. Univariate and multivariate Cox regression models were performed to evaluate the prognostic relevance. Results ROC curve showd that the cutoff value of preoperative dNLR was 2.0 and 161 patients were then divided into high dNLR group （n=78） and low dNLR group （n=83）. Preoperative dNLR was associated with tumor size and histological grade （P＜0.05）， but not with age and lymph node metastasis （P＞0.05）. Patients in high dNLR group had shorter median OS （45.9 months vs. 78.1 months） and DFS （18.1months vs. 24.8 months） compared with patients in low group （P＜0.001）. Cox multivariate analysis showed that histological grade and preoperative dNLR were independent factors influencing DFS； while tumor size， histological grade and preoperative dNLR were independent factors influencing OS. Conclusion Preoperative dNLR can be considered as an independent factor influencing survival in patients with triple negative breast cancer.

Key words:

Triple negative breast cancer；Neutrophil count／white cell count-neutrophil count（dNLR）；Prognosis ')">"> Triple negative breast cancer；Neutrophil count／white cell count-neutrophil count（dNLR）；Prognosis