Abstract:

Objective  To summarize the clinicopathological characteristics， diagnosis and therapy as well as the prognostic factors of patients with thymic squamous cell carcinoma （TSCC）. Methods Twenty-four patients with TSCC admitted to Beijing Chest Hospital from January 2006 to April 2013 were retrospectively analyzed. Among them， 15 cases received surgical treatment （10 cases of combined radiotherapy and chemotherapy after operation， 3 cases of chemotherapy after operation， 1 case of radiotherapy after operation and 1 case without adjuvant treatment after operation） and 9 cases received palliative radiotherapy and chemotherapy. The clinical data of TSCC patients were analyzed. Follow-up data were collected and survival analysis was performed by Kaplan-Meier method. Results All patients were followed up for 1.0 to 139.0 months with a median follow-up time of 53.2 months. The overall survival （OS） was 2.5-139.0 months with a median OS of 68.1 months. The 1-， 3- and 5-year survival rates were 70.8％， 54.2％ and 41.7％， respectively. Kaplan-Meier univariate analysis indicated that Masaoka stage （P=0.018）， surgical resection （P=0.016） and surgical resection integrity （P=0.017） were the prognostic factors of TSCC patients. Postoperative radiotherapy did not prolong the patients’ prognosis （P=0.401）. Conclusion The clinical manifestation of TSCC is lack of specificity. Surgery is the main treatment. Masaoka stage and surgery have an impact on the prognosis of patients. Radical surgery has a better prognosis than palliative surgery. Postoperative radiotherapy has not been able to benefit patients’ survival. Clinical treatment should be formulated according to the physical condition of patients and the integrity of tumor resection.

Key words:

Thymic squamous cell carcinoma（TSCC）')">"> Thymic squamous cell carcinoma（TSCC）, Clinical features, Surgery, Prognosis