宫颈癌,放射性直肠损伤,硫糖铝,保留灌肠," /> 宫颈癌,放射性直肠损伤,硫糖铝,保留灌肠,"/> Cervical cancer,Radiation proctitis,Sucralfate,Retention enema,"/> <span>Clinical observation of sucralfate retention enema on preventing acute and chronic radiation proctitis in patients with cervical cancer</span>

Chinese Clinical Oncology ›› 2022, Vol. 27 ›› Issue (03): 244-249.

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Clinical observation of sucralfate retention enema on preventing acute and chronic radiation proctitis in patients with cervical cancer

  

  • Received:2021-01-29 Revised:2022-01-14 Online:2022-03-25 Published:2022-05-12

Abstract:  Objective  To investigate the efficacy of simultaneous sucralfate retention enema during radiotherapy on preventing the occurrence of acute and chronic radiation proctitis in patients with cervical cancer, and to evaluate the impact on the clinical symptoms and quality of life. Methods  From January 2017 to June 2019, 208 cases of cervical cancer patients underwent radiation were enrolled in this study, and they were divided into experimental group (n=104) and control group (n=104) according to the random number table method. Patients in experimental group received simultaneous sucralfate retention enema during radiotherapy once daily. RTOG/EORTC table, simple clinical colitis activity index (SCCAI) questionnaire and inflammatory bowel diseases questionnaire (IBDQ) were used to evaluate all patients. Results  The incidences of acute radiation proctitis in experimental group and control group were 35.6% and 58.5%, respectively (P=0.000), and the occurrence of acute radiation proctitis was 21.3 days and 17.4 days (P=0.000). Grade 1, grade 2 and grade 3 acute radiation proctitis were found 19,15 and 3 cases in experimental group, and 22, 31 and 8 cases in control group. The incidences of chronic radiation proctitis in experimental group and control group were 9.6% and 22.1%, respectively (P=0.012), and and the occurrence of chronic radiation proctitis was 10.1 months and 9.2 months, respectively (P=0.235). Grade 1, grade 2, grade 3 and grade 4 chronic radiation proctitis were found 3, 4, 2, and 1 cases in experimental group and 4, 9, 8 and 2 cases in control group. Patients in experimental group had lower SCCAI scores than the control group at the end of radiotherapy, 3 months and 12 months after radiotherapy (P<0.05), while the IBDQ score was higher than that in the control group (P<0.05). Conclusion  Sucralfate retention enema during radiotherapy can effectively reduce the risk of acute and chronic radiation proctitis in patients with cervical cancer and improve the patients' clinical symptoms and quality of life.

Key words: font-size:10.5pt, Cervical cancer">Cervical cancerfont-size:10.5pt, ')">">, font-size:10.5pt, Radiation proctitis">Radiation proctitisfont-size:10.5pt, ')">">, font-size:10.5pt, Sucralfate">Sucralfatefont-size:10.5pt, ')">">, font-size:10.5pt, Retention enema')">">Retention enema

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