Abstract:

Objective To evaluate the midlong term outcomes of patients with early breast cancer who received breastconserving treatment （BCT）. Methods The data of 232 early breast cancer patients， who received BCT in Cancer Hospital， Chinese Academy of Medical Sciences from January 1st， 1999 to December 31st， 2005， were collected and analyzed retrospectively. All the cases received extensive lumpectomy or quadrant resection plus axillary lymph nodes dissection， and then radiotherapy， chemotherapy or endocrinotherapy were arranged postoperatively according to the clinical features of patients. Results The median time of followup were 54 months and the mean time were 57.14 months （2-118 months）. Three cases got local recurrences; 15 cases had distant metastases， and 7 cases died. One case received mastectomy because of local recurrence. As to the location of metastasis， 8 cases were found in lungs， 5 cases in livers， 6 cases in brains and 8 cases in bones. Kaplan-Meier method showed the 3-year and 5-year overall survival rates were 99.06％ and 96.98％， respectively. The 3-year and 5-year diseasefree survival rates were 97.01％ and 93.23％， respectively. The 3-, 5-year overall survival rates of 52 patients with larger tumor （＞2cm） were lower than those of 171 patients with smaller tumor （≤2cm）， showing with significant differences （P＜0.05）， and the 3-, 5-year overall survival rates of 52 patients without endocrinotherapy were significantly lower than those of 171 patients receiving endocrinotherapy （P＜0.05）. The 3-, 5-year disease-free survival rates of lymph nodes positive patients were significantly lower than those of lymph nodes negative patients （P＜0.05）. Conclusion Conforming to the indication of breast conservation， BCT is safe and feasible for early breast cancer.