Abstract: Objective To investigate the expression of α-basic-crystallin（αB-crystallin） in basal-like breast cancer（BLBC），and analyze the association between its expression and the clinicopathological characteristics in BLBC. MethodsThe SP immunohistochemical technique was used to examine the expression of αB-crystallin in 108 cases of BLBC and 342 cases of non-basal-like breast cancer（NBLBC）. Results By statistical analysis， it showed that the positive rate of αB-crystallin was 56.5％ in BLBC， significantly higher than 7.9％ in NBLBC（P＜0.05）. The expression of αB-crystallin was found to be positively correlated with histological grading of tumor（r=0.313，P＜0.001）， but not with age， tumor size and lymph node metastasis（P＞0.05）. ConclusionαB-crystallin may play an important role in the progression of BLBC. Furthermore，it also may be a marker which can predict poor clinical outcome in BLBC.