Abstract: Objective To evaluate the efficacy and side effects of thalidomide in the treatment of advanced soft tissue sarcoma and impact on quality of life. Methods Twenty-two patients with advanced soft tissue sarcoma were given thalidomide 100mg per day and up to 200mg per day seven days later， at the same time patients were given aspirin 75mg per day orally. The efficacy， side effects and quality of life were evaluated every 2 months. Results Two（9.1％） patients had PR， four patients（18.2％） had SD, and disease control rate was 27.3%. Median time to progression was 1 month， median overall survival was 5 months， and the rate of improved quality of life was 136％. The main side effects were constipation， fatigue， somnolence， which were mostly in grade 1-2, and other adverse reactions were rare. Conclusion Thalidomide regimen as third-line treatment for patients with advanced soft tissue sarcoma is effective， and it can improve life quality， and the side effects can be tolerable.