Abstract: Objective To observe the clinical efficacy and adverse reactions of oxycodone hydrochloride controlledrelease tablets for lung cancer survivors with moderate and severe pain， and evaluate the influences on the quality of life under medical institutionscommunity medical service mode.
Methods Sixty-three lung cancer patients with moderate and severe pain were enrolled. The numerical rating pain rating（NRS） and the European Organization for Research and Treatment of Cancer（EORTC） QLQ-C30 questionnaire were employed to evaluate the pain degree and quality of life before and after the treatment of oxycodone hydrochloride controlledrelease tablets. Then community physicians would be in charge of subsequent treatment， including pain treatment， psychological intervention and follow-up. EORTC QLQ-C30 questionnaire was employed and a comparative analysis was conducted 4 weeks later. Results After analgesic treatment， the overall response rate of pain was 90.5％. The remission rates in moderate and severe pain were 94.1％ and 86.2％, respectively. The main adverse reactions including nausea， vomiting and constipation were relieved or disappeared after proper treatment. The social function， emotional function， physical function， role function, pain， insomnia and overall quality of life were significantly improved after analgesic treatment（P＜0.05）. Compared with the pretreatment， the overall quality of life in both moderate and severe pain group were statistically improved（P＜0.05）. And the psychological intervention could effectively improve the qualite of life（P＜0.05）. Conclusion The analgesic therapy with oxycodone hydrochloride controlledrelease tablets can effectively relieve the pain and improve the qualite of life in lung cancer patients. Establishing an effective comprehensive psychological intervention in medical institutionscommunity health service model can effectively improve the qualite of life for lung cancer survivors.