Abstract: Objective To investigate the clinical manifestations, pathologic features, differentiation and diagnosis of retroperitoneal paraganglioma.
Methods The clinical manifestations， histopathologic morphology, immunohistologic features, treatment and prognosis were analyzed in 32 cases of retroperitoneal paraganglioma， and the literatures were reviewed. Results Low back pain was the main symptoms of retroperitoneal paraganglioma， and patients often accompanied by increased blood pressure. Blood vessels were rich in the neoplasm of retroperitoneal paraganglioma， and pathologic diagnosis showed that the cells of tumors were rich in cytoplasm， and some were basophilic. Immunohistochemical study showed that CgA， Syn， S-100， Ki-67（2％-30％）were positively expressed， while Melan-A and CK were negative. Surgical resection was the main treatment of this disease. Thirteen cases were followed up, and no recurrence and metastasis was found. Conclusion The diagnosis of retroperitoneal paraganglioma should be confirmed by morphologic features and immunophenotypes. Patients should be followed-up， and it has a potential of maligancy.