Abstract: Objective To detect the serum pyridinoline cross-linked N-telopeptides of type Ⅰ collagen （NTx） level of giant cell tumor of bone（GCT） patients， and to investigate the effects of zoledronic acid and surgery on it. Methods Thirty-five GCT patients were enrolled， and randomly divided into group A and group B. Patients in group A were given zoledronic acid （Zometa） and surgery， while patients in group B only received surgery. Blood collection was performed before and after the treatments. Level of serum NTx were tested by ELISA method. Factors affecting the serum NTx level of GCT patients were analyzed by single factor analysis of variance. Results For group A， NTx levels after zoledronic acid were （28.50±7.06） and （21.38±3.33） nmol BCE／L before and after zoledronic acid（P＜0.05）， and then dropped to （20.60±3.28）nmol BCE／L after surgery（P＜0.05）. For group B， NTx levels were （26.05±4.37） and （24.38±3.56） nmol BCE／L before and after surgery（P＜0.05）. The change rate of NTx after treatment in group A was higher than that in group B（P＜0.05）. According to statistical analysis， the serum NTx level of GCT patients all decreased significantly after receiving zoledronic acid， surgery and zoledronic acid plus surgery （P＜0.05）. Tumor location was found to be a significant influential factor of serum NTx level （P＜0.05）. Conclusion The serum NTx level of the GCT patients can be decreased by either zoledronic acid or surgery，showing the potential value in assisting the diagnosis and treatment of GCT.
【Key Words】Giant cell tumor of bone；Zoledronic acid；Pyridinoline cross-linked N-telopeptides of type Ⅰ collagen （NTx）