Abstract: Objective To compare the difference of clinical staging of cervical cancer with operative pathological staging， further to explore the risk factors for lymph node metastasis. Methods The clinicopathologic parameters in 181 inpatients with Federation International of Gynecology and Obstetrics （FIGO）stageⅠA-ⅡB cervical cancer in the First Affiliated Hospital of Xinjiang Medical University from January 2010 to January 2014 were retrospectively analyzed. The risk factors for lymph node metastasis were evaluated by the way of univariate X2 statsistic analysis and binary Logistic regression analysis.
ResultsThe coincidence rates of FIGO stages ⅠA， ⅠB， ⅡA， ⅡB with surgical stage were 57.9％， 73.6％， 52.1％ and 39.5％， respectively. The overall accuracy rate of the clinical staging was 59.1％ （107／181）. ⅠA， ⅠB， ⅡA， ⅡB periods of lymph node metastasis rates were 10.5％， 13.1％， 27.1％ and 50.0％, respectively. Univariate analysis showed that the serum level of squamous cell carcinoma antigen （SCCA）， clinical stage， tumor size， neoadjuvant chemotherapy， deep stromal invasion， vascular invasion and uterine tissue invasion were associated with pelvic lymph node metastasis（P＜0.05）. Multivariate analysis showed that SCCA， FIGO stage， deep myometrial invasion， vascular tumor thrombus were the independent risk factor for lymph node metastasis（P＜0.05）. Neoadjuvant chemotherapy could reduce the metastatic lymph nodes. Conclusion With the increasing FIGO stage， the lower rate of two stages in accuracy， the higher rate of lymph node metastasis. Study on risk factors of cervical cancer with lymph node metastasis can provide references for individual treatment.