Abstract: Oxaliplatin is the thirdgeneration platinum compound with the some advantages of high efficiency， low toxicity and difficult to resistant etc， thus obviously different from other first- and second-generation platinum drugs. Recent studies have shown that in addition to cytotoxic effect of oxaliplatin that is direct action in cancer cell DNA， immunological mechanism is a new and very important aspect of its anti-tumour effect. Thus this paper want to briefly review the study progression of immunological mechanisms in oxaliplatin antitumour effect and its clinical implications，to help oncologists understanding related issues and expanding treatment as well as research thought.