Abstract: Objective To investigate the expression of Maspin and Bmi-1 in nasopharyngeal carcinoma and their relationship with clinical pathological characteristics.
Methods An immunohistochemical method was used to detect the expression of Maspin and Bmi-1 proteins in 60 nasopharyngeal carcinoma samples and 40 adjacent normal nasopharyngeal tissues. Then the relationship between Maspin, Bmi-1 expression and clinicopathological features was analyzed. Results The positive expression rate of Maspin in nasopharynegeal carcinoma and normal tissues was 45.0%（27/60） and 90.0%（36/40） with significant difference（P＜0.05）. The positive expression rate of Bmi1 in nasopharyngeal carcinoma and normal tissues was 75.0％（45／60） and 25.0％（10／40）， and the difference was statistically significant（P＜0.05）. The expression of Maspin and Bmi-1 was not correlated with the age（P＞0.05）， but with the degree of malignancy， lymph node metastasis and clinical stage （P＜0.05）.The expression of Maspin and Bmi-1 in nasopharyngeal carcinoma showed significant negative correlation（r=-0.406，P＜0.05）. Conclusion The expression of Maspin and Bmi-1 plays an important role in the occurrence and progression of nasopharyngeal carcinoma.