Abstract:

Objective To evaluate safety and efficacy of CT-guided percutaneous microwave ablation in pulmonary metastases from colorectal cancer. Methods From June 2010 to June 2015， 48 unresectable lesions in 32 patients with pulmonary metastases from colorectal cancer were selected for CT-guided microwave ablation. Kaplan-Meier method was used for survival analysis， and multivariable analysis of prognostic factors was done by Cox regression model. Results Among the 48 lesions of 32 patients， the complete response was achieved in 42 patients （87.5%）. No death was observed within 30 days after ablation， and no needle tract implantation metastases happened. Pneumothorax was found in 6 cases. All the patients were followed up. The median progression-free survival time was 26 months （95%CI： 16.790-35.210 months）. The 1， 2 and 3-year progression-free survival rates were 79.5%， 62.8% and 43.1%， respectively. Univariate analysis showed that tumor size， tumor-free interval and number of tumors were significantly related to progression-free survival time （P＜0.05）. Multivariate analysis showed that tumor size was an independent prognostic factor for progression-free survival （P＜0.05）.
Conclusion CT-guided percutaneous microwave ablation is a safe， effective and minimally invasive method to treat pulmonary metastases from colorectal cancer.