Abstract: Objective To investigate the correlation of vascular endothelial growth factor C（VEGF-C），and vascular endothelial growth factor receptor 3（VEGFR-3）with the infection of helicobacter pylori（Hp）and clinicopathological characteristics in gastric carcinoma. Methods The infection with Hp in 40 patients with gastric carcinoma was detected by 13C breath test and improved Giemsa. The expression of VEGF-C，VEGFR-3 in 40 cases of gastric carcinoma and their adjacent tissues were detected by immunohistochemical SP method. Results The infection of Hp in 40 gastric carcinoma patients was 65.0％. The expressions of VEGF-C，VEGFR-3 in gastric carcinoma tissues were（8.74±0.84）×10-2 and（3.64±1.96）×10-2，and in adjacent tissues they were（1.23±0.38）×10-2 and（0.90±0.18）×10-2. The expressions of VEGF-C，VEGFR-3 in gastric carcinoma were significantly higher than those of adjacent tissues（P＜0.05）. There was a positive correlation between VEGF-C and VEGFR-3（r=0.51，P＜0.05）. The expressions of VEGF-C，VEGFR-3 were related to the depth of invasion，differentiation，lymph node metastasis and TNM stage（P＜0.05）, but not with tumor size（P＞0.05）. The expression of VEGF-C，VEGFR-3 in Hp-positive gastric carcinoma tissues were（11.72±3.07）×10-2 and（8.71±2.15）×10-2，which were higher than （8.48±1.11）×10-2and（5.37±1.05）×10-2 in Hp-negative gastric carcinoma tissues，with significant differences（P＜0.05）. Conclusion Infection of Hp and the expressions of VEGF-C，VEGFR-3 are associated with the ooccurrence and progression of gastric carcinoma. The infection of Hp may be correlated with lymphangiogenesis.