Abstract: Metastasis associated gene 2（MTA2）is a member of metastasis-associated gene family. Protein alignment homology of human MTA proteins and coding sequence of functional domain revealed high homology of MTA2 with MTA1. MTA2 is one of the components of nucleosome remodeling deacetylase（NuRD）complex which have chromatin remodeling and histone deacetylating properties. It can also interact with some transcription factors and involve into gene transcriptional regulation. MTA2 is overexpressed in various kinds of malignancies and closely associated with tumor invasion and metastasis，which indicates that MTA2 may play vital role in tumor metastasis. Herein，we will review the expression，biological function and the molecular mechanism of MTA2 in tumor invasion and metastasis.