Abstract: Objective To evaluate dose effect and prognosis of radiotherapy for ⅠE stage non-conjunctival primary ocular adnexal mucosa associated lymphoid tissue lymphoma （POAML）. Methods The data of 33 patients （42 eyes） with non-conjunctival POAML from Nov. 2003 to Mar. 2012 were retrospectively analyzed. Results When the irradiation doses were 18 Gy and 27 Gy， the remission rates of WHO criteria were 31％ and 42.9％ （P=0.258）， respectively. The remission rates of RECIST criteria were 28.6％ and 38.1％ （P=0.355）， respectively. Thirty-three patients with local control rate was 100％.The 5-， 10-year survival rates and disease-free survival rate of the patients were 96.8％， 84.7％ and 89.6％， 89.6％. The 5-，10-year survival rates of patients received 30.6 Gy and 27 Gy were 100％， 95.7％， 80％ and 95.7％ （P=0.8578）； 5 years and 10 years disease-free survival rates were 83.3％， 91.1％， 83.3％ and 91.1％ （P=0.6497）. Conclusion Non conjunctiva POAML is sensitive to radiotherapy. 27 Gy irradiation dose can achieve better local control and long-term survival. Exploring the optimal dose of radiation requires a prospective large dose effect study.