临床肿瘤学杂志 ›› 2017, Vol. 22 ›› Issue (12): 1143-1146.

• • 上一篇    下一篇

白头翁皂苷D抗肿瘤的研究进展

  

  1. 250014济南山东中医药大学第一临床医学院
  • 收稿日期:2017-01-04 修回日期:2017-10-23 出版日期:2017-12-31 发布日期:2018-06-21

Progression on antitumor of pulchinenoside D#br#

  1. First Clinical Medical College,Shandong University of Traditional Chinese Medicine
  • Received:2017-01-04 Revised:2017-10-23 Online:2017-12-31 Published:2018-06-21

摘要: 白头翁皂苷D是白头翁众多有效单体成分中在抗肿瘤方面研究最广泛、效价最高的单体,是近年来抗肿瘤药物研究的热点之一。白头翁皂苷D通过抑制肿瘤细胞增殖、促进肿瘤细胞凋亡、抑制能量代谢、调节自噬以及抑制肿瘤细胞迁移和转移等方面抑制肿瘤生存,现就近年来白头翁皂苷D抗肿瘤方面的相关研究进行综述。

关键词:

肿瘤, 白头翁皂苷D, 细胞凋亡, 细胞自噬

Abstract: Pulchinenoside D is the most widely and the highest titer monomer of many effective monomer components of Baitouweng in antitumor researches, which is one of the research hotspots of antitumor drugs in recent years. Pulchinenoside D inhibits tumor survival by inhibiting proliferation and promoting apoptosis of tumor cells, inhibiting energy metabolism, regulating autophagy and inhibiting tumor cell migration and metastasis. In this review, we collected related studies on antitumor of pulchinenoside D in recent years, which may provide new ideas for tumor treatment.


Key words: Tumor, Pulchinenoside D, Apoptosis, Autophagy

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