Abstract:

Objective To calculate the normal tissue complication probability（NTCP）and the tumor control probability（TCP）of intensity modulated radiotherapy（IMRT）plan for nasopharyngeal carcinoma（NPC）by using an equivalent uniform dose（EUD）. Methods As a high-level technical computing language with friendly interface and mathematical properties，Matlab was chosen to implement the EUD-based Lyman-Kutcher-Burman NTCP mathematical model and Schultheiss TCP logistic model. The normal tissue and target dose-volume histogram（DVH）of three patients with NPC were obtained from Elekta precise treatment planning system. The necessary parameters for the model were clearly defined. Results The computer code is presented and saved as a Matlab program. The EUD and NTCP values of four normal tissues from three NPC patients were generated and the TCP values were further gained. Conclusion The model has an excellent ability in fitting the normal structures tolerance values in this study. It is helpful for clinicians to select safer and more effective treatment plans. In future，the program will be modified and tested in radiotherapy for prostate and lung cancer.