关键词:  , 生物标志物')">">生物标志物, 抗血管生成药物, 疗效, 预测因子

Abstract:  The development of new blood vessels not only serves to supply the tumor tissue with nutrients， but they can also serve as a means for cancer cells to metastasize. Anti-angiogenic therapy for cancer has gradually become an important way of cancer therapy. The widespread use of anti-angiogenic drugs in clinical practice not only brings benefits to patients but also brings side effects and economic burdens. Therefore more and more researches on predictive biomarkers to anti-angiogenesis therapies have been carried out. Some studies have found that vascular endothelial growth factor（VEGF）／vascular endothelial growth factor receptor（VEGFR） pathway related factors， cytokines of CXC chemokine family and other angiogenic regulators can predict the efficacy of anti-angiogenic drugs. However， the conclusions of different studies are not exactly the same， and the related predictors are not widely accepted. This article reviews the predictive effects of biomarkers on anti-angiogenic drugs.

Key words: font-family:宋体, Biomarker">Biomarkerfont-family:宋体, ')">">, Anti-angiogenic drugs, Effect, Predictor