关键词: 肺癌, 脑转移, 临床特征, 影像学特征

Abstract: ObjectiveTo investigate the clinical and imaging features of lung cancer patients with brain metastases. 
MethodsThe clinical data of 228 lung cancer patients with brain metastases treated by radiotherapy department of Jiangsu cancer hospital from January 2014 to December 2016 were retrospectively analyzed. 
ResultsOf the 228 patients， 140 were males and 88 were females， with a median age of 60 years， 171 cases of adenocarcinoma， 35 cases of small cell carcinoma， and 22 cases of squamous cell carcinoma. There were 93 cases of brain metastases and 135 asymptomatic patients. The median time to diagnosis of metastatic brain tumors was 5 months， and 890％ patients were diagnosed with brain metastases within 2 years. The median time of diagnosis was 3 months and 6 months for patients with or without extracranial metastases. The difference was statistically significant （P＜005）. There were 227 cases of brain metastases， 149 cases of supratentorial metastasis， 15 cases of simple subtentorial metastasis， and 63 cases of supratentorial and subtentorial metastasis. The frontal（528％） and parietal（448％） lobes were the most common sites in the patients with supratentorial metastases. There were significant differences in the distribution of single and multiple foci in brain metastases of different pathological types （P＜005）. 
ConclusionBrain metastases are more frequent in patients with lung cancer within two years. The risk of brain metastases is higher in one year with other organ metastases. Brain metastases from lung cancer usually occur frequently， with metastases mostly on the supratentorial.

Key words: Lung cancer, Brain metastasis, Clinical features, Imaging features