PET/CT双时相显像在预测宫颈癌淋巴结转移中的价值

摘要/Abstract

摘要：

目的探讨PET/CT双时相显像在预测宫颈癌淋巴结转移中的价值。方法回顾性分析2019年1月至2021年7月行PET/CT早期及延迟显像（双时相）的97例宫颈癌患者202枚淋巴结的影像学资料，测量早期显像淋巴结代谢参数SUVmaxL1、SUVmean、SUVpeak、MTV、TLG、长短径比（L/D）、病灶SUVmaxT、腹主动脉SUVmaxA、肝脏SUVmaxH及延迟显像淋巴结代谢参数SUVmaxL2，计算各相应比值及△SUVmax（SUVmaxL2' SUVmaxL1）、溜滞指数（RI）。比较各参数在淋巴结转移组（n=42）与非转移组（n=160）之间的差异，联合传统诊断标准行Logistic多因素回归分析，分别建立联合预测诊断模型，绘制受试者工作特征（ROC）曲线并比较诊断效能。结果淋巴结转移组与非转移组SUVmaxL1、SUVmean、SUVpeak、MTV、TLG、L/D、SUVmaxL2、△SUVmax、RI、SUVmaxL1/T、SUVmaxL1/A和SUVmaxL1/H 的差异均有统计学意义（P<0.001）。Logistic多因素回归分析显示，SUVpeak、L/D,传统PET/CT诊断标准和SUVmaxL2为影响宫颈癌淋巴结转移的独立因素。传统PET/CT诊断标准的曲线下面积（AUC）为0.839，灵敏度为67.7%，特异度为87.5%；单时像联合预测诊断模型的AUC为0.915，灵敏度、特异度分别为83.3%和85.6%；双时相联合预测诊断模型的AUC为0.995，灵敏度、特异度分别为97.6%和98.7%。单时相联合预测诊断模型的AUC高于传统PET/CT诊断标准，双时相联合预测诊断模型的AUC高于传统PET/CT诊断标准，双时相联合预测诊断模型的AUC大于单时像联合预测模型，差异均有统计学意义（P<0.05）。结论单时相及双时相联合预测诊断模型诊断宫颈癌淋巴结转移的效能均高于传统诊断标准，同时双时相联合预测诊断模型的诊断效能显著高于单时相联合预测诊断模型。

关键词: font-size:10.5pt, 宫颈癌')">">宫颈癌, font-size:10.5pt, PET/CT">PET/CTfont-size:10.5pt, 双时相显像')">">双时相显像, 淋巴结转移

Abstract:

Objective To investigate the value of PET/CT biphasic imaging in predicting lymph node metastasis of cervical carcinoma. Methods We retrospectively analyzed 202 lymph nodes from January 2019 to July 2021 in 97 patients with cervical carcinoma who underwent surgery and had preoperative PET/CT for early and delayed imaging (duplex). The metabolic parameters of lymph nodes in early imaging, such as SUVmaxL1, SUVmean, SUVpeak, MTV, TLG, length-short diameter ratio (L/D), SUVmaxT of lesions, SUVmaxA of abdominal aorta, SUVmaxH of liver, and SUVmaxL2 of lymph nodes in delayed imaging were measured. The corresponding ratios, △SUVmax (SUVmaxL2-SUVmaxL1) and retention index (RI) were calculated. The differences of each parameter between lymph node metastasis group(n=42) and non-metastasis group(n=160) were compared. Multivariate regression analysis was performed in combination with traditional diagnostic criteria to establish a combined predictive diagnostic model. Receiver operating characteristic (ROC) curve was used to compare the diagnostic efficacy. Results SUVmaxL1, SUVmean, SUVpeak, MTV, TLG, L/D, SUVmaxL2, △SUVmax, RI, SUVmaxL1/T, SUVmaxL1/A and SUVmaxL1/H were significantly different between metastasis and non-metastasis groups, and Logistic multi-factor regression analysis showed that SUVpeak, L/D, conventional PET/CT diagnostic criteria and SUVmaxL2 were independent risk factors for lymph node metastasis of cervical cancer; the area under curve (AUC) of conventional PET/CT diagnostic criteria was 0.839, with a sensitivity of 67.7 % and specificity of 87.5%; the AUC of single-temporal combined predictive diagnostic model was 0.915, with a sensitivity and specificity of 83.3% and 85.6%, respectively; the AUC of dual'temporal combined predictive diagnostic model was 0.995, with a sensitivity and specificity of 97.6% and 98.7%, respectively. The AUC of the single-temporal combined predictive diagnostic model was higher than that of the conventional PET/CT diagnostic criteria, the AUC of the dual-temporal combined predictive diagnostic model was higher than that of the conventional PET/CT diagnostic criteria, and the AUC of the dual-temporal combined predictive diagnostic model was higher than that of the single-temporal image.The difference was statistically significant (P<0.05). Conclusion The diagnostic efficacy of single-temporal and dual'temporal combined predictive diagnostic models for lymph node metastasis is higher than that of conventional diagnostic criteria, and the diagnostic efficacy of dual-temporal combined predictive diagnostic model is significantly higher than that of single-temporal combined predictive diagnostic model.

Key words: , Cervical cancer')">">, PET/CT biphasic imaging')">">, Lymph node metastasis

周魏薇, 宋丽萍. PET/CT双时相显像在预测宫颈癌淋巴结转移中的价值[J]. 临床肿瘤学杂志, 2022, 27(03): 232-237.

ZHOU Weiwei, SONG Liping.. Value of PET/CT biphasic imaging in predicting lymph node metastasis of cervical carcinoma[J]. Chinese Clinical Oncology, 2022, 27(03): 232-237.

0
/ / 推荐 PET/CT双时相显像在预测宫颈癌淋巴结转移中的价值”的文章，特向您推荐。请打开下面的网址：http://manu65.magtech.com.cn/Jwk3_lczlxzz/CN/abstract/abstract2580.shtml' name="neirong"> PET/CT双时相显像在预测宫颈癌淋巴结转移中的价值'>

导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

链接本文: http://manu65.magtech.com.cn/Jwk3_lczlxzz/CN/

http://manu65.magtech.com.cn/Jwk3_lczlxzz/CN/Y2022/V27/I03/232

参考文献

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed

本文评价

推荐阅读 10

[1]	石　玮¹，华海清²，王兴华¹. 放疗对肠屏障功能的影响及研究进展[J]. 临床肿瘤学杂志, 2009, 14(1): 89 .
[2]	钟克力¹，张　丽²，戴　勇²，周汉新²，王春友¹. 采用染色质免疫沉淀联合芯片技术分析胃癌全基因组蛋白Ｈ３Ｋ２７三甲基化水平[J]. 临床肿瘤学杂志, 2009, 14(1): 15 .
[3]	钱　莘¹，丁金勇²，吕　军¹，陈正堂². ＣＣＡ＋ＳＰ-Ｃ＋细胞和ＣＤ１３３＋细胞在人肺腺癌组织分布的初步研究[J]. 临床肿瘤学杂志, 2009, 14(1): 6 .
[4]	林文照，林英城，王鸿彪，曾　德，林　懿，林　雯，杜彩文. 雷莫司琼崩解片防治化疗所致恶心呕吐的临床研究[J]. 临床肿瘤学杂志, 2009, 14(1): 59 .
[5]	杨　斌，陈赛英，史佃云，张佃乾. 宫颈癌术前介入化疗前后组织中Ｓｕｒｖｉｖｉｎ、Ｃａｓｐａｓｅ-３和Ｃａｓｐａｓｅ-７的表达变化及意义[J]. 临床肿瘤学杂志, 2009, 14(1): 39 .
[6]	侯　军，章卫平，邱慧颖，郑晓丽，王利平，倪　雄，宋献民，王健民. 自体外周血干细胞移植治疗Ｔ细胞淋巴瘤的临床研究[J]. 临床肿瘤学杂志, 2009, 14(2): 102 .
[7]	陈　建^1,许　林¹. 局部晚期非小细胞肺癌的外科治疗现状[J]. 临床肿瘤学杂志, 2009, 14(2): 183 .
[8]	刘扬清¹，高　勇¹，万一元¹，易竹筠¹，惠红霞¹，徐丽娟¹，刘　华¹. 大蒜素对结肠癌ＬｏＶｏ细胞增殖的影响[J]. 临床肿瘤学杂志, 2009, 14(2): 139 .
[9]	李建军，黄海辉，潘　凤，边志衡，胡绍毅，梁后杰. 透明质酸酶增强５-ＦＵ对结肠癌抗癌作用的动物实验研究[J]. 临床肿瘤学杂志, 2009, 14(2): 134 .
[10]	时淑珍¹，赵俊军²，赵卫红¹，徐晓辉¹. ＦＨＩＴ和ｍｄｍ２蛋白在非小细胞肺癌中的表达及意义[J]. 临床肿瘤学杂志, 2009, 14(3): 212 .